What term is used to describe the effects that PEDs can have on an athlete’s health?

The term "significant" is appropriate when describing the effects that Performance-Enhancing Drugs (PEDs) can have on an athlete's health because these substances can lead to profound and serious health consequences. The use of PEDs can result in a range of physical and psychological side effects, including hormonal imbalances, organ damage, increased risk of heart disease, mood swings, and dependency issues. Given the potential for severe repercussions on both short-term and long-term health, "significant" accurately reflects the gravity of the impact these substances can have on an individual's well-being and athletic performance.

In contrast, terms like "minor" or "recreational" downplay the seriousness of the health outcomes associated with PED usage, which is not reflective of the potential risks. Similarly, "anticipated" suggests that the effects might be predictable or controllable, which is misleading given the variable and often unpredictable nature of how different individuals respond to these drugs.